Around 60 firefighters from ten fire crews were tackling the fire, which has caused huge disruption across the city.
The station was cleared out after the fire broke out at around 6.25am. Flames were seen coming from the station's roof and smoke filled the foyer.
The station is now closed, with no trains arriving or departing, and is set to remain shut all day. A number of roads have also been closed.
Nottingham City Transport is not serving any stops at the station or at Arkwright Street.
Emergency services said no injuries were reported.